You can only use one database to track the poker site at a time.
If the PLO and 5 card PLO games are played on different sites, you can just enable the poker site on one of the database and have it disabled the other database.
If both games are played on the same site, open only one database for the game type ou wnat to track. open DH2 for 5 card plo and open HM3 for the regulat PLO.